Archive for May, 2010|Monthly archive page

Optogenetic: A new way to control body function through the switch of light

In Science on 07/05/2010 at 6:38 AM

Today, i decide to wake up at 6h30am in the morning to attend early lecture. It turns out more exciting than i thought πŸ™‚ For 10 minutes,my lecturer has talked about : optogenetics as a new and accuracy method to study function of different brain areas. And this is one of the coolest ideas i heard πŸ™‚ Image that you, one day, can command your pets to poop in your neighborhood yard (for revenge ?) by pressing a button in your dog control remote or discover the deep sea/dangerous area by controlling native animals through Xbox controller πŸ™‚

So how does it work ? Through brain researches, we know that neurons used chemical compounds (Neurotransmitters) to communicate with each others. For example: Acetylcholine, Adrenaline and Noradrenaline, these compounds will determine whenever neurons should “talk” to each other or not.Β  And to be able to produce these compounds, the cell will need to translate DNA sequences (Stored in its nucleus) into protein sequences which represent these neurotransmitters. They are kind of like money printing processes where you need to get money printing plate to be able to produce legitimate cash:-). So if you can modify DNA sequences to stop cells from producing these neurotransmitters or increase the production of other enzymes that kill these signals (All most compounds cell produce will need to get from DNA banks), the communication of this neurons region will be stopped ! Like shutting down face region so that no expressions: happy, sad or angry can be seen)

But how can we change DNA sequences into tiny/wienie cells ? Well, viruses are among excellent candidates to inject engineered DNA sequences into cells. (A good reason for the existence of viruses :-)) If we take some specific viruses which their activities changed during present of specific light color, we have our own behavior remote or optogenetic πŸ™‚ Of course, the mechanics of this method might be more complicated but this is what i understand about optogenetic. Here is an interesting Youtube video about this method:

So basically, the idea is to use light-sensitive viruses to control the protein synthesis within this mouse motor cortex.Therefore when a specific wave length (color) light switch on, it will alter the communication signalsΒ  between theses cells and changing mouse running behavior. Pretty good, eh ?

I, myself dream of someday will hold this remote in my hand πŸ˜‰ a

Or if you are a girl, you should consider to buy this product:

Men remote control


Fender Squire Bullet Strat: Good first electric guitar

In Electric guitars on 05/05/2010 at 4:07 AM

It has been 1 year since i started to self -taught electric guitar. I admit it is quite a challenge for me at first due to the fact that some of the finger lessons are so hard that i just want to thrown my guitar away and play Guitar hero instead. I know it sound bad, folks but at least this game give me some quick shortcuts to perform hard smoking rock songs, which would take me about 2 years to be able to play with the real guitar. And the ironic is when i had quite familiar with my Fender Squier fret board, i hardly can play any Guitar Hero songs above 90% now. It is true that if you are good at playing the real guitar, it will not guarantee a successful in playing expert mode in Guitar Hero and vice verse. So yes, if you really want to play it your way guitar, you should put down the plastic console, buy the real one and start playing straight away.

My first attempt to buy a guitar was turn out to be very lucky as i got electric guitar pack with a good prize (250$) and the guitar has been tuned up ready for action. I read a lot of the articles in the internet about how to buy first guitar but they were a bit confusing. I mean how on earth you can judge this guitar is better than these others if you, the buyer are not actually hold and playing the guitar itself. And maybe the tones from these recommended guitars might not be your liking ? So my first advice is you should buy your guitar in a local store so you can test all of it function and more importantly if something wrong happen, you can away bring it back for checking or swapping. Don’t be shy just pick up any guitars from the store and play it (I am sure staffs are happy to help your as a beginner guitarist πŸ˜‰ That is why i am not recommend Ebay as your first choice. It is true that you can find really good deal in Ebay for example: my second guitar AXL Mayhem Jacknife with only 100$ in about 95% condition. However, you will need to know really good about what you intend to buy or you need to have someone experience and close to help you.

Consider myself as 1 year self-taught and played 5 guitars: Fender Squirer Bullet Strat, Fatboy LP style guitar, AXL Mayhem Jacknife, Epiphone studio version and ESP Kirk Hamlet signature ( Got a bargian on this one only 380$), i would recommend Fender Squire Bullet Strat the most. Why ?

  • And more importantly it give you a bright clean sound good enough to recognize your own mistake and fix the buzz when moving between the fret board. I often use it when i practice Paul Gilbert alternative picking exercises as i can easily hear any bad string pressing/muting when i increase my speed.
  • About the prize, i bought it as a pack 250$ along with lead, DVD metal method first season and Fender Sp-10 (I know a lot of people complaint about this Amp distortion ability but i think it is a perfect match with Fender Squire Bullet Strat in term of delivering a good bright clean sound, suitable for blue or Jimi Hendrix play along season). You can bought these guitars off Ebay with the prize around 80-100$ included postage so unless you can go and test the guitar i strongly recommend you as beginner should buy what you actually can hear and play ! Some people from Ultimate guitar forum report different quality with same Fender Squire guitar model so make sure to try different Bullet Strat guitars to find the most comfortable tone and suitable with your fingers.

So for short: if you are looking for a first well-know brand guitar and tight on your budget: Fender Squire Bullet Strat is my recommendation

You can find more information about this guitar on Ultimate Guitar or Harmony Central. This guitar actually has high score rating: 7.3 and 8.7 respectively when compare to its price

Other ways to unlock/jailbreak iPhone 3G firmware 3.1.3 baseband 05.12.01 Bootloader 5.8

In Apple device on 03/05/2010 at 2:51 AM


  • Bad news folks, some of the guys pointed out this iPhone has bootloader 5.8. That is why this method worked 😦
  • So to make sure you can UNLOCK the device, you need to download “f0recast” software from
  • Run this software, it will tell if you are able to downgrade your baseband and unlock !
  • If yes, run Cydia and search for “Fuzzyband Downgrader”Β  install and run. And Then let it Sn0w !


Yes you read it right, folks ! I am able to install blackrain into my friend iPhone 3G firmware 3.1.3 baseband 05.12.01 sucessfully. And after having blackra1n appear in my friend home screen, the rest is just deadly simple: install Cydia and Unlock phone are 2 fingers away πŸ™‚ The phone specs before the unlock is: Firmware 3.1.3 (Update through iTunes) baseband: 05.12.01 and after the unlock: Firmware 3.1.2 (7D11) baseband: 05.12.01

How can i do it ?

I guess it was my lucky day πŸ™‚ You will need:

  1. iPhone 3G firmware 3.1.2
  2. Blackra1n from Geohotz website
  3. Patience and time cuz you will need to restore the device 3 or 4 times

Ok enough typing here they are:

  1. Connect your phone to iTunes and do normally downgrade to firmware 3.1.2 (Shift click restore)
  2. Ok and when you nearly finish, iTunes will display some stupid errors: 16xx or 2…. It is normal !
  3. Now your iPhone should stuck in Recovery mode like this picture:
  4. iPhone recover mode
  5. That is a good sign. Now next is very long process: What i basically do is run Blackra1n again and again until you can see GeoHotz picture appear in your screen. And then your iphone will have his wonderful application ! Remember that if the iPhone appears black screen for 10mins after you press Make It Ra1n, just reboot it by holding the 2 buttons and run blackra1n again !
  6. Based on my friend phone, it normally took me about 2 times to get GeoHotz screen.( I did the downgrade process 5,6 times to make sure and they were all sucess πŸ™‚ It seems to me that Apple fix is not good enough to 100% block GeoHotz exploit

I did it. How about yours?

  1. I need someone to confirm that this method work on every iPhone accidentally upgrade to 3.1.3. So please if you are successful please post your result
  2. Also i want to confirm that the solder joint i did to my friend’s phone has nothing to do with this downgrade. (My skill at solder is terrible so i am not willingly unsolder and solder the joint myself 😦